Category: DOORM

Based on these mechanisms, emerging drug development directions are focusing on regulating the dynamic balance of condensates, which aligns with the traditional Chinese medicine principle of “harmonizing Yin and Yang.” In the field of health preservation, the autophagy mechanism studied in the 2016 Nobel Prize research has been confirmed to be regulated by condensates. The…

基于这些机制，新兴药物研发方向正着眼于调节凝聚体的动态平衡，这与中医“调和阴阳”的治疗理念不谋而合。在养生领域，2016年诺贝尔奖研究的细胞自噬机制已被证实受凝聚体调控。传统养生法中通过调炁促进健康的现象，或许正是通过影响细胞凝聚体的功能状态，激活细胞自噬等维护机制来实现的。 [Float-Menu id=”1″]

In terms of medical applications, this understanding also demonstrates significant value. Traditional Chinese medicine posits that the essence of disease lies in “Yin-Yang imbalance,” while modern research has found that diseases related to protein misfolding, such as Alzheimer’s and autism, are indeed closely associated with the dysfunction of condensate functions. In cancer research, the malfunction…

在医学应用层面，这种理解也展现出重要价值。中医认为疾病本质在于“阴阳失调”，而现代研究发现阿尔兹海默症、自闭症等与蛋白质错误折叠相关的疾病，确实与凝聚体功能紊乱密切相关。在癌症研究中，凝聚体对DNA的监控功能失常被认为是癌变诱因之一。病毒学研究也发现，SARS等病毒会特异性地攻击细胞凝聚体以逃避免疫清除。 [Float-Menu id=”1″]

From the perspective of the origin of life, this discovery also supports the “RNA world” hypothesis. The earliest life molecules may have existed in a membrane-less form as RNA, self-organizing to form condensates, which then evolved into organelles and complete cells. This process resembles the cosmic creation model of “Tai Chi generating the two forms”:…

从生命起源角度看，这一发现也支持“RNA世界”假说。最初的生命分子可能是以无膜形态存在的RNA，通过自组织形成凝聚体，进而演化出细胞器与完整细胞。这一过程恰如“太极生两仪”的宇宙生成模型：原始RNA如同先天之炁，其弥散状态属阳，凝聚状态属阴，阴阳和合而化生万物。 [Float-Menu id=”1″]

These membrane-less structures are dispersed throughout the cell and even constitute the cell’s cytoskeleton (as confirmed by research in 2022). When needed, they can rapidly gather to form functional bodies, completing specific tasks before dispersing again. This characteristic of “gathering to form shape, dispersing to become Qi” aligns closely with the traditional Chinese medicine assertion…

这些无膜结构弥散于整个细胞空间，甚至构成细胞骨架（2022年研究证实）。在需要时，它们能迅速聚集形成功能体，完成特定任务后再度消散。这种“聚则为形，散则为氣”的特性，与中医理论中“阴主凝聚，阳主发散”的论述高度契合。 [Float-Menu id=”1″]

By the 2010s, with advancements in microscopy, scientists finally confirmed that the nucleolus is a “biomolecular condensate” formed by the aggregation of RNA and RNA-binding proteins through weak interactions. More than 30 such structures have now been identified within cells, and their functions can be broadly categorized into four types: Assembling ribosomes to synthesize other…

直到2010年代，随着显微技术的进步，科学家终于确认核仁是由RNA与RNA结合蛋白通过弱相互作用聚集形成的“生物分子凝聚体”。目前已在细胞内发现30多种此类结构，功能大致可归纳为四类： 1. 组装核糖体，进而合成其他细胞组分； 2. 感知外界环境变化，及时启动细胞应对机制。例如当辐射导致DNA断裂时，凝聚体可率先进行修复，维持遗传稳定性； 3. 参与基因表达调控，决定特定基因是否表达； 4. 作为生化反应的催化平台，加速特定合成过程。 [Float-Menu id=”1″]